Voltage-gated L-type calcium channel · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P22002. Use UniProt P22002 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22002 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-gated L-type calcium channel, mapped to UniProt P22002. ChEMBL maps the protein component as Voltage-dependent L-type calcium channel subunit alpha-1C. Sequence length is 2169 aa.
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This review treats Voltage-gated L-type calcium channel as ChEMBL target CHEMBL2095177, mapped to UniProt P22002. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Voltage-gated L-type calcium channel |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P22002 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent L-type calcium channel subunit alpha-1C |
| UniProt Accession | P22002 |
| Component Type | Protein |
| Sequence Length | 2169 aa |
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-gated L-type calcium channel, mapped to UniProt P22002. ChEMBL maps the protein component as Voltage-dependent L-type calcium channel subunit alpha-1C. Sequence length is 2169 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL33165 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL277363 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL2093893 | 9.69 | Ki | 0.205 | Preclinical |
| CHEMBL21906 | 9.54 | Ki | 0.29 | Preclinical |
| CHEMBL139748 | 9.54 | Ki | 0.29 | Preclinical |
| CHEMBL277363 | 9.38 | IC50 | 0.42 | Preclinical |
| CHEMBL1314450 | 9.3 | Ki | 0.499 | Preclinical |
| CHEMBL139748 | 9.11 | IC50 | 0.78 | Preclinical |
| CHEMBL21906 | 9.11 | IC50 | 0.78 | Preclinical |
| CHEMBL1484 | 9.08 | Ki | 0.84 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 82 | 71 | 6.5 |
| assay format | 67 | 48 | 6.8 |
| tissue-based format | 53 | 98 | 6.5 |
| cell-based format | 21 | 42 | 5.7 |
| cell membrane format | 6 | 9 | 6.5 |
| subcellular format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 12 | 63 | 7.1 |
| assay format | 11 | 0 | — |
| cell-based format | 4 | 5 | 5.7 |
| cell membrane format | 1 | 1 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 2 | 5.2 |