Assay Detail
Binding
CHEMBL1099883
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Inhibition of GBA1 by HPLC
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.91 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574645 | — | — | 1 | 6.70 |
| CHEMBL1088158 | — | — | 1 | 6.70 |
| CHEMBL1086996 | — | — | 1 | 5.70 |
| CHEMBL1088292 | — | — | 1 | 4.52 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | - |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | - |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | - |
| CHEMBL175901 | — | — | 1 | - |
| CHEMBL1076754 | — | — | 1 | - |
| CHEMBL110458 | MIGALASTAT | 4.0 | 1 | - |
| CHEMBL1086997 | LUCERASTAT | 3.0 | 1 | - |
| CHEMBL179409 | — | — | 1 | - |
| CHEMBL1088291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574645 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1088158 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1086996 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1088292 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 250000.0 | nM | - |
| CHEMBL1561 | MIGLITOL | IC50 | = | 200000.0 | nM | - |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 400000.0 | nM | - |
| CHEMBL175901 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1076754 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL110458 | MIGALASTAT | IC50 | = | 350000.0 | nM | - |
| CHEMBL1086997 | LUCERASTAT | IC50 | = | 320000.0 | nM | - |
| CHEMBL179409 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1088291 | — | IC50 | > | 1000000.0 | nM | - |