Compound Detail
CHEMBL1561
MIGLITOL 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1561 |
| Name | MIGLITOL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IBAQFPQHRJAVAV-ULAWRXDQSA-N |
| Therapeutic | ✓ Yes |
13
Targets
69
Activities
3
Assay Types
8
PK Parameters
20
Publications
6
Known Names
3
Indications
2
Mechanisms
Molecular Properties
207.2
MW (Da)
-3.26
ALogP
6
HBA
5
HBD
104.4
PSA (Ų)
0.33
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1996 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Maltase-glucoamylase inhibitor | INHIBITOR | Maltase-glucoamylase | ✓ | ✓ |
| Lysosomal alpha-glucosidase inhibitor | INHIBITOR | Lysosomal alpha-glucosidase | ✓ | ✓ |
Indications
Diabetes Mellitus Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 1
ATC Classification
A10BF02
miglitol
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS USED IN DIABETES
Activity Summary
IC50 50 meas. best 7.3
Ki 17 meas. best 7.55
Kd 2 meas. best 4.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 7.55 | 6.2315 | 28.0 | 13 |
| Unchecked CHEMBL612545 | IC50 | 7.3 | 6.3163 | 50.0 | 8 |
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 6.96 | 5.582 | 110.0 | 10 |
| Lysosomal alpha-glucosidase CHEMBL2608 | IC50 | 6.46 | 6.0533 | 350.0 | 3 |
| Glycogen debranching enzyme CHEMBL5273 | IC50 | 6.41 | 6.41 | 390.0 | 1 |
| Acidic alpha-glucosidase CHEMBL3513 | Ki | 6.34 | 6.34 | 460.0 | 1 |
| Sucrase-isomaltase, intestinal CHEMBL2748 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 6.23 | 5.975 | 590.0 | 4 |
| Maltase-glucoamylase CHEMBL2074 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Maltase-glucoamylase CHEMBL2074 | IC50 | 5.43 | 5.36 | 3700.0 | 3 |
| Unchecked CHEMBL612545 | Kd | 4.68 | 4.68 | 20640.0 | 1 |
| Alpha-glucosidase CHEMBL5291954 | IC50 | 4.46 | 4.46 | 34500.0 | 1 |
| Lactase/phlorizin hydrolase CHEMBL1075131 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
| Alpha-glucosidase CHEMBL3435 | IC50 | 4.24 | 4.24 | 57140.0 | 1 |
| Alpha-mannosidase CHEMBL3392945 | IC50 | 4.12 | 4.12 | 75880.0 | 1 |
| Lysosomal acid glucosylceramidase CHEMBL2179 | IC50 | 4.08 | 4.08 | 84000.0 | 1 |
| Beta-galactosidase CHEMBL3482 | Ki | 4.0 | 4.0 | 100000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | - | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| Fu | 1.0 | - | Homo sapiens |
| Fu | 1.0 | - | Homo sapiens |
| MRT | 2.7 | hr | Homo sapiens |
| T1/2 | 2.3 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine