Assay Detail
Binding
CHEMBL1645861
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Inhibition of Wistar rat small intestine maltase after 30 mins
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.09 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 6.80 |
| CHEMBL476960 | VOGLIBOSE | 4.0 | 1 | 6.75 |
| CHEMBL1641739 | — | — | 1 | 6.70 |
| CHEMBL1641744 | — | — | 1 | 6.50 |
| CHEMBL1641743 | — | — | 1 | 6.42 |
| CHEMBL1641742 | — | — | 1 | 6.29 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 6.23 |
| CHEMBL1641741 | — | — | 1 | 6.15 |
| CHEMBL1641746 | — | — | 1 | 6.08 |
| CHEMBL1641747 | — | — | 1 | 5.92 |
| CHEMBL1645621 | — | — | 1 | 5.77 |
| CHEMBL1645620 | — | — | 1 | 5.58 |
| CHEMBL1641748 | — | — | 1 | 5.41 |
| CHEMBL1641749 | — | — | 1 | 4.60 |
| CHEMBL1641745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL476960 | VOGLIBOSE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1641739 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1641744 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1641743 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1641742 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1641741 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1641746 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1641747 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1645621 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1645620 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1641748 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1641749 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1641745 | — | IC50 | = | 500000.0 | nM | - |