Compound Detail
CHEMBL1641744
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Basic Information
| ChEMBL ID | CHEMBL1641744 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SDYXGHBDCJJNMV-CYDGBPFRSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
245.4
MW (Da)
0.79
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.48
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 6.5 | 6.5 | 320.0 | 2 |
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 6.35 | 5.235 | 450.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acidic alpha-glucosidase | IC50 | = | 320.0 | nM | 6.5 | Inhibition of Wistar rat small intestine maltase after 30 mins | 21185187 |
| Acidic alpha-glucosidase | IC50 | = | 320.0 | nM | 6.5 | Inhibition of rat intestinal maltase using moltose as substrate | 23106358 |
| Sucrase-isomaltase, intestinal | IC50 | = | 450.0 | nM | 6.35 | Inhibition of Wistar rat small intestine sucrase after 30 mins | 21185187 |
| Sucrase-isomaltase, intestinal | IC50 | = | 450.0 | nM | 6.35 | Inhibition of rat intestinal sucrase using sucrose as substrate | 23106358 |
| Sucrase-isomaltase, intestinal | IC50 | = | 75000.0 | nM | 4.12 | Inhibition of Wistar rat small intestine isomaltase after 30 mins | 21185187 |
| Sucrase-isomaltase, intestinal | IC50 | = | 75000.0 | nM | 4.12 | Inhibition of rat intestinal isomaltase using isomaltase as substrate | 23106358 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21185187 | 10.1016/j.bmcl.2010.11.112 | Sucrase-isomaltase, intestinal | 2 |
| 23106358 | 10.1021/jm301304e | Sucrase-isomaltase, intestinal | 2 |
| 21185187 | 10.1016/j.bmcl.2010.11.112 | Acidic alpha-glucosidase | 1 |
| 21185187 | 10.1016/j.bmcl.2010.11.112 | Unchecked | 1 |
| 21185187 | 10.1016/j.bmcl.2010.11.112 | Lactase/phlorizin hydrolase | 1 |
| 23106358 | 10.1021/jm301304e | Acidic alpha-glucosidase | 1 |
Data from ChEMBL 36 via Core Engine