Assay Detail
Binding
CHEMBL3815263
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Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.51 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814496 | — | — | 1 | 7.38 |
| CHEMBL3814988 | — | — | 1 | 7.05 |
| CHEMBL3815109 | — | — | 1 | 7.05 |
| CHEMBL3814838 | — | — | 1 | 6.92 |
| CHEMBL3814911 | — | — | 1 | 6.62 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 6.37 |
| CHEMBL3814747 | — | — | 1 | 6.34 |
| CHEMBL3814555 | — | — | 1 | 6.30 |
| CHEMBL3814264 | — | — | 1 | 5.89 |
| CHEMBL1182462 | — | — | 1 | 5.89 |
| CHEMBL239249 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814496 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3814988 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3815109 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3814838 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3814911 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3814747 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3814555 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3814264 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1182462 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL239249 | — | IC50 | = | 1600.0 | nM | 5.80 |