Compound Detail

CHEMBL1182462

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ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1182462
Phase	Preclinical
Structure Type	MOL
InChI Key	UOUAEIUEKYLOBU-VVWMKKEXSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

255.3

MW (Da)

-3.58

ALogP

HBA

HBD

121.4

PSA (Å²)

0.28

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 4 meas. best 6.52

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Sucrase-isomaltase, intestinal CHEMBL3114	IC50	6.52	6.205	300.0	2
Unchecked CHEMBL612545	IC50	5.1	5.1	8000.0	1
Maltase-glucoamylase CHEMBL2074	IC50	5.05	5.05	9000.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Sucrase-isomaltase, intestinal	IC50	=	300.0	nM	6.52	Inhibition of rat small intestinal isomaltase using isomaltose as substrate incu...	27325449
Sucrase-isomaltase, intestinal	IC50	=	1300.0	nM	5.89	Inhibition of rat small intestinal sucrase using sucrose as substrate incubated ...	27325449
Unchecked	IC50	=	8000.0	nM	5.1	Inhibition of rat small intestinal maltase using maltose as substrate incubated ...	27325449
Maltase-glucoamylase	IC50	=	9000.0	nM	5.05	Inhibition of human small intestine microsomal maltase using maltose as substrat...	27325449

PubMed	DOI	Target Context	# Activities
27325449	10.1016/j.bmc.2016.06.013	Sucrase-isomaltase, intestinal	2
27325449	10.1016/j.bmc.2016.06.013	Unchecked	1
27325449	10.1016/j.bmc.2016.06.013	Maltase-glucoamylase	1

Data from ChEMBL 36 via Core Engine