Assay Detail
Binding
CHEMBL1837445
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Inhibition of human ntSI expressed in Drosophila S2 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | S2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.53 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276973 | DE-O-SULFONATED KOTALANOL | — | 1 | 7.92 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 6.83 |
| CHEMBL2374473 | BLINTOL | — | 1 | 6.80 |
| CHEMBL1208974 | SALACINOL | — | 1 | 6.56 |
| CHEMBL1093264 | KOTALANOL | — | 1 | 6.22 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276973 | DE-O-SULFONATED KOTALANOL | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1561 | MIGLITOL | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL2374473 | BLINTOL | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL1208974 | SALACINOL | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL1093264 | KOTALANOL | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL404271 | ACARBOSE | Ki | = | 14000.0 | nM | 4.85 |