Assay Detail
Binding
CHEMBL993573
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Inhibition of rabbit muscle amylo-1,6-glucosidase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen debranching enzyme (CHEMBL5273) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.66 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501355 | — | — | 1 | 6.96 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 6.72 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 6.41 |
| CHEMBL108084 | FAGOMINE | — | 1 | 5.68 |
| CHEMBL478209 | — | — | 1 | 5.21 |
| CHEMBL222396 | VALIOLAMINE | — | 1 | 4.51 |
| CHEMBL476960 | VOGLIBOSE | 4.0 | 1 | 4.16 |
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501355 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL108084 | FAGOMINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL478209 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL222396 | VALIOLAMINE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL476960 | VOGLIBOSE | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 480000.0 | nM | - |