Assay Detail
Binding
CHEMBL1837441
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Inhibition of mouse his-tagged ctMGAM-N2 expressed in Sf9 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.32 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 8.05 |
| CHEMBL2374473 | BLINTOL | — | 1 | 7.75 |
| CHEMBL1276973 | DE-O-SULFONATED KOTALANOL | — | 1 | 7.58 |
| CHEMBL1093264 | KOTALANOL | — | 1 | 7.19 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 6.68 |
| CHEMBL1208974 | SALACINOL | — | 1 | 6.67 |
| CHEMBL1908365 | MALTOSE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL2374473 | BLINTOL | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1276973 | DE-O-SULFONATED KOTALANOL | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1093264 | KOTALANOL | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL1561 | MIGLITOL | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL1208974 | SALACINOL | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL1908365 | MALTOSE | Ki | = | 1590000.0 | nM | - |