Assay Detail
Binding
CHEMBL1100206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain AChE by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.36 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 9.00 |
| CHEMBL1080691 | — | — | 1 | 8.38 |
| CHEMBL1080319 | — | — | 1 | 8.19 |
| CHEMBL1082185 | — | — | 1 | 8.14 |
| CHEMBL1080692 | — | — | 1 | 8.07 |
| CHEMBL74926 | PHENSERINE | — | 1 | 7.92 |
| CHEMBL74950 | — | — | 1 | 7.52 |
| CHEMBL1081300 | — | — | 1 | 7.41 |
| CHEMBL1080317 | — | — | 1 | 7.18 |
| CHEMBL1080318 | — | — | 1 | 7.18 |
| CHEMBL1082186 | — | — | 1 | 6.95 |
| CHEMBL1076615 | — | — | 1 | 6.77 |
| CHEMBL1081473 | — | — | 1 | 6.58 |
| CHEMBL1081464 | — | — | 1 | 6.36 |
| CHEMBL1080515 | — | — | 1 | 6.13 |
| CHEMBL1080937 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1080691 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1080319 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1082185 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1080692 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL74950 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL1081300 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL1080317 | — | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL1080318 | — | IC50 | = | 66.2 | nM | 7.18 |
| CHEMBL1082186 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1076615 | — | IC50 | = | 168.1 | nM | 6.77 |
| CHEMBL1081473 | — | IC50 | = | 264.3 | nM | 6.58 |
| CHEMBL1081464 | — | IC50 | = | 441.8 | nM | 6.36 |
| CHEMBL1080515 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL1080937 | — | IC50 | = | 914.3 | nM | 6.04 |