Assay Detail
Binding
CHEMBL1100207
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Inhibition of rat plasma BChE by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.06 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74950 | — | — | 1 | 8.24 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 8.12 |
| CHEMBL1082185 | — | — | 1 | 8.07 |
| CHEMBL1080691 | — | — | 1 | 7.85 |
| CHEMBL1076615 | — | — | 1 | 7.83 |
| CHEMBL1080317 | — | — | 1 | 7.40 |
| CHEMBL1080937 | — | — | 1 | 7.21 |
| CHEMBL1081473 | — | — | 1 | 7.05 |
| CHEMBL74926 | PHENSERINE | — | 1 | 6.98 |
| CHEMBL1081300 | — | — | 1 | 6.98 |
| CHEMBL1080319 | — | — | 1 | 6.95 |
| CHEMBL1080318 | — | — | 1 | 6.29 |
| CHEMBL1080515 | — | — | 1 | 6.08 |
| CHEMBL1082186 | — | — | 1 | 6.03 |
| CHEMBL1081464 | — | — | 1 | 5.99 |
| CHEMBL1080692 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74950 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1082185 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1080691 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL1076615 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL1080317 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL1080937 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL1081473 | — | IC50 | = | 88.7 | nM | 7.05 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 103.7 | nM | 6.98 |
| CHEMBL1081300 | — | IC50 | = | 105.4 | nM | 6.98 |
| CHEMBL1080319 | — | IC50 | = | 113.5 | nM | 6.95 |
| CHEMBL1080318 | — | IC50 | = | 516.8 | nM | 6.29 |
| CHEMBL1080515 | — | IC50 | = | 829.9 | nM | 6.08 |
| CHEMBL1082186 | — | IC50 | = | 935.3 | nM | 6.03 |
| CHEMBL1081464 | — | IC50 | = | 1021.6 | nM | 5.99 |
| CHEMBL1080692 | — | IC50 | = | 1397.5 | nM | 5.86 |