Assay Detail
Binding
CHEMBL1100658
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Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.60 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14690 | CLOBENPROPIT | — | 1 | 8.62 |
| CHEMBL1076267 | — | — | 1 | 8.33 |
| CHEMBL1081541 | — | — | 1 | 8.08 |
| CHEMBL1080089 | — | — | 1 | 7.92 |
| CHEMBL1081719 | — | — | 1 | 7.89 |
| CHEMBL1081718 | — | — | 1 | 7.89 |
| CHEMBL1080263 | — | — | 1 | 7.82 |
| CHEMBL1079553 | — | — | 1 | 7.72 |
| CHEMBL1080262 | — | — | 1 | 7.68 |
| CHEMBL1079552 | — | — | 1 | 7.54 |
| CHEMBL1081720 | — | — | 1 | 7.52 |
| CHEMBL1080090 | — | — | 1 | 7.51 |
| CHEMBL1079747 | — | — | 1 | 7.43 |
| CHEMBL1079918 | — | — | 1 | 7.39 |
| CHEMBL1079554 | — | — | 1 | 7.38 |
| CHEMBL14638 | CIPROXIFAN | — | 1 | 7.34 |
| CHEMBL1076266 | — | — | 1 | 7.31 |
| CHEMBL1076275 | — | — | 1 | 7.28 |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | 7.22 |
| CHEMBL1076300 | — | — | 1 | 7.13 |
| CHEMBL1079746 | — | — | 1 | 7.12 |
| CHEMBL1079748 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14690 | CLOBENPROPIT | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1076267 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL1081541 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL1080089 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1081719 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1081718 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1080263 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1079553 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1080262 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1079552 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1081720 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1080090 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1079747 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1079918 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL1079554 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL14638 | CIPROXIFAN | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL1076266 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL1076275 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL260374 | THIOPERAMIDE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1076300 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL1079746 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL1079748 | — | Ki | = | 91.0 | nM | 7.04 |