Histamine H3 receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Histamine H3 receptor shows approved-linked disease relevance led by narcolepsy-cataplexy syndrome. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9Y5N1. Start with narcolepsy-cataplexy syndrome, then reuse UniProt Q9Y5N1 as the stable protein anchor across project notes and exports.
Start with narcolepsy-cataplexy syndrome, then reuse UniProt Q9Y5N1 as the stable protein anchor across project notes and exports.
Histamine H3 receptor shows approved-linked disease relevance led by narcolepsy-cataplexy syndrome. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with narcolepsy-cataplexy syndrome because it currently carries approved-linked support. Linked drugs include PITOLISANT, PITOLISANT HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHistamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt Q9Y5N1. Sequence length is 445 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H3 receptor as ChEMBL target CHEMBL264, mapped to UniProt Q9Y5N1. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Histamine H3 receptor is the right protein anchor across sources, using UniProt Q9Y5N1 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why narcolepsy-cataplexy syndrome is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Histamine H3 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y5N1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H3 receptor |
| UniProt Accession | Q9Y5N1 |
| Component Type | Protein |
| Sequence Length | 445 aa |
Histamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt Q9Y5N1. Sequence length is 445 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Histamine H3 receptor shows approved-linked disease relevance led by narcolepsy-cataplexy syndrome. 5 more disease programs remain visible in the same review block.
Start review with narcolepsy-cataplexy syndrome because it currently carries approved-linked support. Linked drugs include PITOLISANT, PITOLISANT HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL272077 | 10.72 | Kd | 0.01905 | Preclinical |
| CHEMBL401683 | 10.7 | Kd | 0.01995 | Preclinical |
| CHEMBL258349 | 10.65 | Kd | 0.02239 | Preclinical |
| CHEMBL3094128 | 10.6 | Ki | 0.02512 | Preclinical |
| CHEMBL3753475 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL508712 | 10.51 | Ki | 0.03125 | Preclinical |
| CHEMBL257208 | 10.44 | Kd | 0.03631 | Preclinical |
| CHEMBL18661 | 10.4 | EC50 | 0.03981 | Preclinical |
| CHEMBL272699 | 10.4 | Kd | 0.03981 | Preclinical |
| CHEMBL455288 | 10.38 | Ki | 0.042 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 314 | 2,401 | 7.7 |
| single protein format | 297 | 1,184 | 7.8 |
| assay format | 16 | 203 | 7.6 |
| cell membrane format | 11 | 128 | 6.6 |
| tissue-based format | 2 | 0 | — |
| organism-based format | 1 | 1 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 154 | 922 | 8.2 |
| assay format | 70 | 450 | 8.0 |
| cell membrane format | 3 | 6 | 9.2 |
| organism-based format | 2 | 0 | — |
| single protein format | 2 | 2 | 8.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 1 | 6.0 |
| single protein format | 1 | 0 | — |