Assay Detail
Binding
CHEMBL1100708
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Inhibition of human erythrocyte AChE after 5 mins by Ellman's method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.63 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 7.00 |
| CHEMBL1081810 | — | — | 1 | 6.70 |
| CHEMBL225689 | — | — | 1 | 6.40 |
| CHEMBL430886 | — | — | 1 | 6.16 |
| CHEMBL105742 | — | — | 1 | 5.70 |
| CHEMBL225688 | — | — | 1 | 4.51 |
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | 4.0 | 1 | 4.40 |
| CHEMBL389283 | — | — | 1 | 4.20 |
| CHEMBL1081126 | — | — | 1 | - |
| CHEMBL1081125 | — | — | 1 | - |
| CHEMBL1081124 | — | — | 1 | - |
| CHEMBL1076550 | — | — | 1 | - |
| CHEMBL1081613 | — | — | 1 | - |
| CHEMBL1081449 | — | — | 1 | - |
| CHEMBL1081448 | — | — | 1 | - |
| CHEMBL1088155 | — | — | 1 | - |
| CHEMBL1088019 | — | — | 1 | - |
| CHEMBL1088018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1081810 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL225689 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL430886 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL105742 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL225688 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL389283 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1081126 | — | IC50 | = | 1540000.0 | nM | - |
| CHEMBL1081125 | — | IC50 | = | 2360000.0 | nM | - |
| CHEMBL1081124 | — | IC50 | = | 636000.0 | nM | - |
| CHEMBL1076550 | — | IC50 | = | 1990000.0 | nM | - |
| CHEMBL1081613 | — | IC50 | = | 2290000.0 | nM | - |
| CHEMBL1081449 | — | IC50 | = | 2010000.0 | nM | - |
| CHEMBL1081448 | — | IC50 | = | 1770000.0 | nM | - |
| CHEMBL1088155 | — | IC50 | = | 241000.0 | nM | - |
| CHEMBL1088019 | — | IC50 | = | 1270000.0 | nM | - |
| CHEMBL1088018 | — | IC50 | = | 505000.0 | nM | - |