Assay Detail
Binding
CHEMBL1100709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma BChE after 5 mins by Ellman's method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.22 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081810 | — | — | 1 | 6.10 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 6.10 |
| CHEMBL225689 | — | — | 1 | 5.30 |
| CHEMBL105742 | — | — | 1 | 5.22 |
| CHEMBL430886 | — | — | 1 | 5.16 |
| CHEMBL225688 | — | — | 1 | 4.54 |
| CHEMBL1088155 | — | — | 1 | 4.11 |
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | 4.0 | 1 | - |
| CHEMBL1081126 | — | — | 1 | - |
| CHEMBL1081125 | — | — | 1 | - |
| CHEMBL1081124 | — | — | 1 | - |
| CHEMBL1076550 | — | — | 1 | - |
| CHEMBL1081613 | — | — | 1 | - |
| CHEMBL1081449 | — | — | 1 | - |
| CHEMBL1081448 | — | — | 1 | - |
| CHEMBL389283 | — | — | 1 | - |
| CHEMBL1088019 | — | — | 1 | - |
| CHEMBL1088018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081810 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL225689 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL105742 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL430886 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL225688 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1088155 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | IC50 | = | 16000000.0 | nM | - |
| CHEMBL1081126 | — | IC50 | = | 529000.0 | nM | - |
| CHEMBL1081125 | — | IC50 | = | 1380000.0 | nM | - |
| CHEMBL1081124 | — | IC50 | = | 345000.0 | nM | - |
| CHEMBL1076550 | — | IC50 | = | 1270000.0 | nM | - |
| CHEMBL1081613 | — | IC50 | = | 541000.0 | nM | - |
| CHEMBL1081449 | — | IC50 | = | 2360000.0 | nM | - |
| CHEMBL1081448 | — | IC50 | = | 583000.0 | nM | - |
| CHEMBL389283 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL1088019 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL1088018 | — | IC50 | = | 9800000.0 | nM | - |