Assay Detail
Functional
CHEMBL1101463
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Agonist activity at human S1P3 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
S1P receptor mediated activity of FTY720 phosphate mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.65 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190006 | — | — | 1 | 8.60 |
| CHEMBL1084929 | — | — | 1 | 8.27 |
| CHEMBL1086170 | — | — | 1 | 6.82 |
| CHEMBL1086172 | — | — | 1 | 6.52 |
| CHEMBL1083841 | — | — | 1 | 5.62 |
| CHEMBL1077288 | — | — | 1 | 5.51 |
| CHEMBL1085191 | — | — | 1 | 5.19 |
| CHEMBL1084930 | — | — | 1 | - |
| CHEMBL1086171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190006 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1084929 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1086170 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL1086172 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1083841 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1077288 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1085191 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1084930 | — | EC50 | - | — | - | |
| CHEMBL1086171 | — | EC50 | > | 22000.0 | nM | - |