Assay Detail
Binding
CHEMBL1101550
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Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonance
29
Total Activities
18
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 5.25 | 6.24 |
| Activity | 13 | - | - |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081556 | — | — | 2 | 6.24 |
| CHEMBL1088172 | — | — | 2 | 5.75 |
| CHEMBL1081726 | — | — | 2 | 5.51 |
| CHEMBL473392 | ROBOTNIKININ | — | 2 | 5.51 |
| CHEMBL1081555 | — | — | 1 | 5.35 |
| CHEMBL1079557 | — | — | 2 | 5.24 |
| CHEMBL1079558 | — | — | 2 | 5.06 |
| CHEMBL1087150 | — | — | 1 | 5.05 |
| CHEMBL1076336 | — | — | 1 | 5.00 |
| CHEMBL1080091 | — | — | 2 | 4.62 |
| CHEMBL1080987 | — | — | 1 | 4.42 |
| CHEMBL1080649 | — | — | 2 | - |
| CHEMBL1087529 | — | — | 1 | - |
| CHEMBL1080828 | — | — | 1 | - |
| CHEMBL1076352 | — | — | 2 | - |
| CHEMBL1087530 | — | — | 2 | - |
| CHEMBL1087151 | — | — | 1 | - |
| CHEMBL1080988 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081556 | — | Kd | = | 570.0 | nM | 6.24 |
| CHEMBL1088172 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL473392 | ROBOTNIKININ | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL1081726 | — | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL1081555 | — | Kd | = | 4500.0 | nM | 5.35 |
| CHEMBL1079557 | — | Kd | = | 5700.0 | nM | 5.24 |
| CHEMBL1079558 | — | Kd | = | 8700.0 | nM | 5.06 |
| CHEMBL1087150 | — | Kd | = | 8900.0 | nM | 5.05 |
| CHEMBL1076336 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL1080091 | — | Kd | = | 23800.0 | nM | 4.62 |
| CHEMBL1080987 | — | Kd | = | 38200.0 | nM | 4.42 |
| CHEMBL1080988 | — | Activity | - | — | - | |
| CHEMBL1087151 | — | Inhibition | - | % | - | |
| CHEMBL1081726 | — | Activity | - | — | - | |
| CHEMBL1087530 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL1080649 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL1076352 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL1080988 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL1076352 | — | Activity | - | — | - | |
| CHEMBL1079557 | — | Activity | - | — | - | |
| CHEMBL1080091 | — | Activity | - | — | - | |
| CHEMBL1087529 | — | Activity | - | — | - | |
| CHEMBL1088172 | — | Activity | - | — | - | |
| CHEMBL473392 | ROBOTNIKININ | Activity | - | — | - | |
| CHEMBL1080828 | — | Activity | - | — | - | |
| CHEMBL1080649 | — | Activity | - | — | - | |
| CHEMBL1081556 | — | Activity | - | — | - | |
| CHEMBL1087530 | — | Activity | - | — | - | |
| CHEMBL1079558 | — | Activity | - | — | - |