Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1101671

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human K562 cells assessed as viable cells after 72 hrs by MTS/PMS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Autocuration

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Discorhabdins from the Korean marine sponge Sceptrella sp.
Jeon JE, Na Z, Jung M, Lee HS, Sim CJ, Nahm K, Oh KB, Shin J.
J Nat Prod (2010) 73 : 258 -262
PubMed 20055495 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.16 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1086885 1 5.89
CHEMBL1087539 1 5.68
CHEMBL1086901 1 5.66
CHEMBL1087538 1 5.60
CHEMBL1088179 1 5.60
CHEMBL1088180 1 5.35
CHEMBL1076784 1 5.21
CHEMBL459120 (+)-DISCORHABDIN B 1 5.14
CHEMBL53463 DOXORUBICIN 4.0 1 5.07
CHEMBL509890 MAKALUVAMINE F 1 5.05
CHEMBL447553 DIHYDRODISCORHABDIN C 1 4.70
CHEMBL1087525 DIDEBROMODISCORHABDIN C 1 4.68
CHEMBL453817 MAKALUVAMINE D 1 4.61
CHEMBL509849 DISCORHABDIN C 1 4.60
CHEMBL1086886 1-DEBROMODISCORHABDIN B 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1086885 IC50 = 1300.0 nM 5.89
CHEMBL1087539 IC50 = 2100.0 nM 5.68
CHEMBL1086901 IC50 = 2200.0 nM 5.66
CHEMBL1087538 IC50 = 2500.0 nM 5.60
CHEMBL1088179 IC50 = 2500.0 nM 5.60
CHEMBL1088180 IC50 = 4500.0 nM 5.35
CHEMBL1076784 IC50 = 6100.0 nM 5.21
CHEMBL459120 (+)-DISCORHABDIN B IC50 = 7200.0 nM 5.14
CHEMBL53463 DOXORUBICIN IC50 = 8500.0 nM 5.07
CHEMBL509890 MAKALUVAMINE F IC50 = 8900.0 nM 5.05
CHEMBL447553 DIHYDRODISCORHABDIN C IC50 = 20200.0 nM 4.70
CHEMBL1087525 DIDEBROMODISCORHABDIN C IC50 = 21000.0 nM 4.68
CHEMBL453817 MAKALUVAMINE D IC50 = 24600.0 nM 4.61
CHEMBL509849 DISCORHABDIN C IC50 = 25200.0 nM 4.60
CHEMBL1086886 1-DEBROMODISCORHABDIN B IC50 = 25000.0 nM 4.60