Compound Detail
CHEMBL453817
MAKALUVAMINE D Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL453817 |
| Name | MAKALUVAMINE D |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BBIQXQHDNKDTQK-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
307.4
MW (Da)
1.98
ALogP
4
HBA
3
HBD
77.5
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.1
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| XRS6 | IC50 | = | 80.0 | nM | 7.1 | Cytotoxicity against Chinese hamster Xrs-6 cells | 22686608 |
| K562 | IC50 | = | 24600.0 | nM | 4.61 | Cytotoxicity against human K562 cells assessed as viable cells after 72 hrs by M... | 20055495 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8691207 | 10.1021/np50126a008 | DNA topoisomerase 2-alpha | 1 |
| 8691207 | 10.1021/np50126a008 | HCT-116 | 1 |
| 20055495 | 10.1021/np9005629 | Sortase A | 1 |
| 20055495 | 10.1021/np9005629 | K562 | 1 |
| 20055495 | 10.1021/np9005629 | Salmonella enterica | 1 |
| 20055495 | 10.1021/np9005629 | Proteus vulgaris | 1 |
| 20055495 | 10.1021/np9005629 | Escherichia coli | 1 |
| 20055495 | 10.1021/np9005629 | Staphylococcus aureus | 1 |
| 20055495 | 10.1021/np9005629 | Micrococcus luteus | 1 |
| 20055495 | 10.1021/np9005629 | Bacillus subtilis | 1 |
| 22686608 | 10.1021/jm3002795 | HCT-116 | 1 |
| 22686608 | 10.1021/jm3002795 | XRS6 | 1 |
Data from ChEMBL 36 via Core Engine