Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL614060 Target Snapshot

XRS6 · CELL-LINE · Cricetulus griseus

17Compounds
2Assays
3Approved Drugs
17.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats XRS6 as ChEMBL target CHEMBL614060. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
XRS6
CELL-LINE · Cricetulus griseus
As of 2026-09-14
ChEMBL target ID
CHEMBL614060
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether XRS6 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelXRS6
UniProt AccessionN/A

XRS6

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as XRS6.

Review nameXRS6
OrganismCricetulus griseus
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5017.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL58 8.0 IC50 10.0 Approved
CHEMBL2153157 7.1 IC50 80.0 Preclinical
CHEMBL449905 7.1 IC50 80.0 Preclinical
CHEMBL453817 7.1 IC50 80.0 Preclinical
CHEMBL509186 7.1 IC50 80.0 Preclinical
CHEMBL509890 7.1 IC50 80.0 Preclinical
CHEMBL540397 7.1 IC50 80.0 Preclinical
CHEMBL44657 6.85 IC50 140.0 Approved
CHEMBL43 6.62 IC50 240.0 Approved
CHEMBL341831 5.37 IC50 4300.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
0
6.0
2
6.5
6
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MITOXANTRONE
CHEMBL58
Approved 1987
AMSACRINE
CHEMBL43
Approved 1987
ETOPOSIDE
CHEMBL44657
Approved 1983
Assay Landscape

Assay Landscape

2
Total Assays
10
Tested Compounds
2
Assay Types
ADME — 1 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 6 7.1
Functional — 1 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 10 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine