Compound Detail
CHEMBL509186
MAKALUVAMINE E Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL509186 |
| Name | MAKALUVAMINE E |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SRIGKAHCWXJXIV-SOFGYWHQSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
319.4
MW (Da)
2.42
ALogP
5
HBA
2
HBD
66.6
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| XRS6 CHEMBL614060 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| XRS6 | IC50 | = | 80.0 | nM | 7.1 | Cytotoxicity against Chinese hamster Xrs-6 cells | 22686608 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8691207 | 10.1021/np50126a008 | HCT-116 | 1 |
| 8691207 | 10.1021/np50126a008 | DNA topoisomerase 2-alpha | 1 |
| 8946754 | 10.1021/np9604947 | P388 | 1 |
| 22686608 | 10.1021/jm3002795 | HCT-116 | 1 |
| 22686608 | 10.1021/jm3002795 | XRS6 | 1 |
Data from ChEMBL 36 via Core Engine