Assay Detail
Functional
CHEMBL1101680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vesicular stomatitis virus in EPT cells assessed as inhibition of virus-induced cytopathic effect treated 24 hrs before viral infection measured after 24 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vesicular stomatitis virus |
| Cell Type | EPT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Vesicular stomatitis virus (CHEMBL613739) ↗| Type | ORGANISM |
| Organism | Vesicular stomatitis virus |
Publication
Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.60 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539581 | TILORONE HYDROCHLORIDE | -1.0 | 1 | 5.88 |
| CHEMBL1084906 | — | — | 1 | 5.84 |
| CHEMBL1092507 | — | — | 1 | 5.84 |
| CHEMBL1088347 | — | — | 1 | 5.80 |
| CHEMBL493698 | — | — | 1 | 5.79 |
| CHEMBL1088346 | — | — | 1 | 5.58 |
| CHEMBL1084905 | — | — | 1 | 5.57 |
| CHEMBL1098690 | — | — | 1 | 5.57 |
| CHEMBL1077006 | — | — | 1 | 5.57 |
| CHEMBL1098691 | — | — | 1 | 5.54 |
| CHEMBL1098374 | — | — | 1 | 5.52 |
| CHEMBL1092508 | — | — | 1 | 5.47 |
| CHEMBL1098689 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539581 | TILORONE HYDROCHLORIDE | IC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL1084906 | — | IC50 | = | 1445.44 | nM | 5.84 |
| CHEMBL1092507 | — | IC50 | = | 1445.44 | nM | 5.84 |
| CHEMBL1088347 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL493698 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL1088346 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL1084905 | — | IC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL1098690 | — | IC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL1077006 | — | IC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL1098691 | — | IC50 | = | 2884.03 | nM | 5.54 |
| CHEMBL1098374 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL1092508 | — | IC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL1098689 | — | IC50 | = | 13182.57 | nM | 4.88 |