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Compound Detail

CHEMBL493698

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c1ccc2nc3c(nc2c1)c1ccccc1n3CCN1CCOCC1

Basic Information

ChEMBL ID CHEMBL493698
Phase Preclinical
Structure Type MOL
InChI Key MFVLXWUDVQMAHA-UHFFFAOYSA-N
2
Targets
6
Activities
2
Assay Types
1
PK Parameters
12
Publications
0
Known Names

Molecular Properties

332.4
MW (Da)
3.07
ALogP
5
HBA
0
HBD
43.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H20N4O
MW 332.41
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness -1.36

Activity Summary

IC50 5 meas. best 5.79
EC50 1 meas. best 4.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vesicular stomatitis virus
CHEMBL613739
IC50 5.79 5.6433 1621.8 3
Vaccinia virus
CHEMBL613493
IC50 4.55 4.55 28000.0 1
Vaccinia virus
CHEMBL613493
EC50 4.52 4.52 30000.0 1

Pharmacokinetic Data

Parameter Value Units Species
Ka 5.89 - Bos taurus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine