Assay Detail
Functional
CHEMBL1024879
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Inhibition of Vaccinia virus DNA synthesis in by rapid plate assay
93
Total Activities
93
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of non-nucleoside DNA synthesis inhibitors of vaccinia virus by high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 93 | 4.70 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494487 | — | — | 1 | 6.30 |
| CHEMBL494691 | — | — | 1 | 5.89 |
| CHEMBL494692 | — | — | 1 | 5.52 |
| CHEMBL493889 | — | — | 1 | 5.46 |
| CHEMBL445774 | — | — | 1 | 5.42 |
| CHEMBL541418 | — | — | 1 | 5.40 |
| CHEMBL493863 | — | — | 1 | 5.39 |
| CHEMBL446815 | — | — | 1 | 5.30 |
| CHEMBL522887 | — | — | 1 | 5.28 |
| CHEMBL492418 | — | — | 1 | 5.27 |
| CHEMBL523705 | — | — | 1 | 5.25 |
| CHEMBL494668 | — | — | 1 | 5.23 |
| CHEMBL494669 | — | — | 1 | 5.22 |
| CHEMBL343732 | — | — | 1 | 5.20 |
| CHEMBL523359 | — | — | 1 | 5.17 |
| CHEMBL493866 | — | — | 1 | 5.14 |
| CHEMBL495496 | — | — | 1 | 5.13 |
| CHEMBL493435 | — | — | 1 | 5.13 |
| CHEMBL523375 | — | — | 1 | 5.00 |
| CHEMBL494474 | — | — | 1 | 5.00 |
| CHEMBL492279 | — | — | 1 | 4.92 |
| CHEMBL492467 | — | — | 1 | 4.92 |
| CHEMBL492293 | — | — | 1 | 4.89 |
| CHEMBL492294 | — | — | 1 | 4.85 |
| CHEMBL541417 | — | — | 1 | 4.82 |
| CHEMBL493690 | — | — | 1 | 4.80 |
| CHEMBL492833 | — | — | 1 | 4.75 |
| CHEMBL522005 | — | — | 1 | 4.72 |
| CHEMBL493691 | — | — | 1 | 4.68 |
| CHEMBL492656 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494487 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL494691 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL494692 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL493889 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL445774 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL541418 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL493863 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL446815 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL522887 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL492418 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL523705 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL494668 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL494669 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL343732 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL523359 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL493866 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL495496 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL493435 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL523375 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL494474 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL492279 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL492467 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL492293 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL492294 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL541417 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL493690 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL492833 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL522005 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL493691 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL492656 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL492862 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL507828 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL492863 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL523387 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL494045 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL504180 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL522686 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL492886 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL522173 | AMINDOCATE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL524172 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL493698 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL522174 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL493699 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL522696 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL494079 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL500836 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL504977 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL501131 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL492235 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL492468 | — | IC50 | = | 37000.0 | nM | 4.43 |