Assay Detail
Functional
CHEMBL1101840
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Neuroprotective activity in rat PC12 cells assessed as inhibition of serum deprivation-induced apoptosis after 24 hrs by APO Percentage apoptosis assay
18
Total Activities
18
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 12 | - | - |
| IC50 | 4 | 8.61 | 9.72 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076355 | — | — | 1 | 9.72 |
| CHEMBL90593 | PRASTERONE | 4.0 | 1 | 9.54 |
| CHEMBL1080646 | — | — | 1 | 8.19 |
| CHEMBL1079393 | — | — | 1 | 7.00 |
| CHEMBL1079392 | — | — | 1 | - |
| CHEMBL1088422 | — | — | 1 | - |
| CHEMBL1088421 | — | — | 1 | - |
| CHEMBL1088283 | — | — | 1 | - |
| CHEMBL1088282 | — | — | 1 | - |
| CHEMBL1088281 | — | — | 1 | - |
| CHEMBL1079446 | METHANDRIOL | 2.0 | 1 | - |
| CHEMBL410519 | — | — | 1 | - |
| CHEMBL1079445 | — | — | 1 | - |
| CHEMBL440283 | ANDROSTENEDIOL | -1.0 | 1 | - |
| CHEMBL1076435 | — | — | 1 | - |
| CHEMBL1080647 | — | — | 1 | - |
| CHEMBL1076348 | — | — | 1 | - |
| CHEMBL1082098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076355 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL90593 | PRASTERONE | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL1080646 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1079393 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL1079392 | — | Activity | - | — | - | |
| CHEMBL1088422 | — | Inhibition | - | % | - | |
| CHEMBL1088421 | — | Inhibition | - | % | - | |
| CHEMBL1088283 | — | Inhibition | - | % | - | |
| CHEMBL1088282 | — | Inhibition | - | % | - | |
| CHEMBL1088281 | — | Inhibition | - | % | - | |
| CHEMBL1079446 | METHANDRIOL | Inhibition | - | % | - | |
| CHEMBL410519 | — | Inhibition | - | % | - | |
| CHEMBL1079445 | — | Inhibition | - | % | - | |
| CHEMBL440283 | ANDROSTENEDIOL | Inhibition | - | % | - | |
| CHEMBL1076435 | — | Inhibition | - | % | - | |
| CHEMBL1080647 | — | Inhibition | - | % | - | |
| CHEMBL1076348 | — | Inhibition | - | % | - | |
| CHEMBL1082098 | — | Activity | - | — | - |