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Compound Detail

CHEMBL1076355

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C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CO1

Basic Information

ChEMBL ID CHEMBL1076355
Phase Preclinical
Structure Type MOL
InChI Key LKDLANDMNIFZOI-IJMQKCTASA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

302.5
MW (Da)
4.08
ALogP
2
HBA
1
HBD
32.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H30O2
MW 302.46
Aromatic Rings 0
Heavy Atoms 22
NP-Likeness 2.76

Activity Summary

IC50 2 meas. best 10.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 10.4 10.4 0.0 1
PC-12
CHEMBL612556
IC50 9.72 9.72 0.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19845386 10.1021/jm900468p PC-12 8
19845386 10.1021/jm900468p Estrogen receptor 4
19845386 10.1021/jm900468p Estrogen receptor beta 2
19845386 10.1021/jm900468p Unchecked 1
19845386 10.1021/jm900468p MCF7 1
19845386 10.1021/jm900468p Ishikawa 1
19845386 10.1021/jm900468p LNCaP 1
19845386 10.1021/jm900468p HEK293 1
19845386 10.1021/jm900468p ADMET 1
22506561 10.1021/jm300317k Glucose-6-phosphate 1-dehydrogenase 1

Data from ChEMBL 36 via Core Engine