Assay Detail
Binding
CHEMBL1101960
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Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.16 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080737 | — | — | 1 | 6.80 |
| CHEMBL1081275 | — | — | 1 | 6.77 |
| CHEMBL1081428 | — | — | 1 | 6.77 |
| CHEMBL1081427 | — | — | 1 | 6.75 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | — | 1 | 6.62 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.55 |
| CHEMBL1087623 | — | — | 1 | 6.30 |
| CHEMBL1080541 | — | — | 1 | 6.30 |
| CHEMBL1087152 | — | — | 1 | 6.29 |
| CHEMBL1087663 | — | — | 1 | 6.29 |
| CHEMBL1080386 | PHENETHYLCYMSERINE | — | 1 | 6.27 |
| CHEMBL1086635 | — | — | 1 | 6.26 |
| CHEMBL1080730 | — | — | 1 | 6.14 |
| CHEMBL1086636 | — | — | 1 | 6.14 |
| CHEMBL1080720 | — | — | 1 | 5.96 |
| CHEMBL1080562 | — | — | 1 | 5.58 |
| CHEMBL1080542 | — | — | 1 | 5.48 |
| CHEMBL1076547 | — | — | 1 | 5.00 |
| CHEMBL1076548 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1080737 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1081275 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1081428 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1081427 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1087623 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1080541 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1087152 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1087663 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1080386 | PHENETHYLCYMSERINE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1086635 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1080730 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1086636 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1080720 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1080562 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1080542 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1076547 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1076548 | — | IC50 | = | 15000.0 | nM | 4.82 |