Compound Detail
CHEMBL1080720
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1ccc(CCN2CC[C@@]3(C)c4cc(OC(=O)Nc5ccc(C(C)C)cc5)ccc4N(C)[C@@H]23)c(C)c1
Basic Information
| ChEMBL ID | CHEMBL1080720 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AKMVLODGJKEJFN-CDZUIXILSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
497.7
MW (Da)
7.02
ALogP
4
HBA
1
HBD
44.8
PSA (Ų)
0.40
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholinesterase CHEMBL2528 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cholinesterase | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric meth... | 20137934 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20137934 | 10.1016/j.bmcl.2010.01.057 | Acetylcholinesterase | 1 |
| 20137934 | 10.1016/j.bmcl.2010.01.057 | Cholinesterase | 1 |
| 20137934 | 10.1016/j.bmcl.2010.01.057 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine