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Assay Detail

CHEMBL1102011

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human SST3 receptor
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Somatostatin receptor type 3 (CHEMBL2028)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists.
Troxler T, Hurth K, Schuh KH, Schoeffter P, Langenegger D, Enz A, Hoyer D.
Bioorg Med Chem Lett (2010) 20 : 1728 -1734
PubMed 20137944 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 45 7.09 8.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1076621 1 8.91
CHEMBL1076659 1 8.87
CHEMBL1076620 1 8.65
CHEMBL1076657 1 8.54
CHEMBL1076622 1 8.47
CHEMBL1076624 1 8.15
CHEMBL1076623 1 8.11
CHEMBL1076717 1 8.07
CHEMBL1076709 1 7.97
CHEMBL1076655 1 7.96
CHEMBL1076718 1 7.96
CHEMBL1076710 1 7.85
CHEMBL1082179 1 7.71
CHEMBL1082178 1 7.70
CHEMBL1081442 1 7.68
CHEMBL1076711 1 7.54
CHEMBL1076719 1 7.46
CHEMBL1081441 1 7.24
CHEMBL1079798 1 7.10
CHEMBL1080734 1 7.07
CHEMBL1079969 1 7.04
CHEMBL1081806 1 7.04
CHEMBL1086987 1 7.02
CHEMBL1076715 1 6.97
CHEMBL1076627 1 6.97
CHEMBL1076658 1 6.97
CHEMBL1080733 1 6.93
CHEMBL1076654 1 6.81
CHEMBL1076652 1 6.79
CHEMBL1081836 1 6.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1076621 Kd = 1.23 nM 8.91
CHEMBL1076659 Kd = 1.349 nM 8.87
CHEMBL1076620 Kd = 2.239 nM 8.65
CHEMBL1076657 Kd = 2.884 nM 8.54
CHEMBL1076622 Kd = 3.388 nM 8.47
CHEMBL1076624 Kd = 7.079 nM 8.15
CHEMBL1076623 Kd = 7.762 nM 8.11
CHEMBL1076717 Kd = 8.511 nM 8.07
CHEMBL1076709 Kd = 10.72 nM 7.97
CHEMBL1076655 Kd = 10.96 nM 7.96
CHEMBL1076718 Kd = 10.96 nM 7.96
CHEMBL1076710 Kd = 14.13 nM 7.85
CHEMBL1082179 Kd = 19.5 nM 7.71
CHEMBL1082178 Kd = 19.95 nM 7.70
CHEMBL1081442 Kd = 20.89 nM 7.68
CHEMBL1076711 Kd = 28.84 nM 7.54
CHEMBL1076719 Kd = 34.67 nM 7.46
CHEMBL1081441 Kd = 57.54 nM 7.24
CHEMBL1079798 Kd = 79.43 nM 7.10
CHEMBL1080734 Kd = 85.11 nM 7.07
CHEMBL1079969 Kd = 91.2 nM 7.04
CHEMBL1081806 Kd = 91.2 nM 7.04
CHEMBL1086987 Kd = 95.5 nM 7.02
CHEMBL1076627 Kd = 107.15 nM 6.97
CHEMBL1076658 Kd = 107.15 nM 6.97
CHEMBL1076715 Kd = 107.15 nM 6.97
CHEMBL1080733 Kd = 117.49 nM 6.93
CHEMBL1076654 Kd = 154.88 nM 6.81
CHEMBL1076652 Kd = 162.18 nM 6.79
CHEMBL1081836 Kd = 190.55 nM 6.72
CHEMBL1080754 Kd = 199.53 nM 6.70
CHEMBL1086988 Kd = 239.88 nM 6.62
CHEMBL470331 Kd = 302.0 nM 6.52
CHEMBL1081804 Kd = 331.13 nM 6.48
CHEMBL1081805 Kd = 407.38 nM 6.39
CHEMBL1076686 Kd = 741.31 nM 6.13
CHEMBL461988 Kd = 1047.13 nM 5.98
CHEMBL1076656 Kd = 1122.02 nM 5.95
CHEMBL1076653 Kd = 1230.27 nM 5.91
CHEMBL1087113 Kd = 1258.93 nM 5.90
CHEMBL1076692 Kd = 1348.96 nM 5.87
CHEMBL1076720 Kd = 1584.89 nM 5.80
CHEMBL1079799 Kd = 2398.83 nM 5.62
CHEMBL1088611 Kd = 2691.53 nM 5.57
CHEMBL1076625 Kd = 3630.78 nM 5.44