Assay Detail
Functional
CHEMBL1102239
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Antiproliferative activity against mouse Sal cells expressing human IGF-1R assessed as [3H]thymidine incorporation after 72 hrs by scintillation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Sal |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.69 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505919 | — | — | 1 | 7.11 |
| CHEMBL401766 | — | — | 1 | 6.96 |
| CHEMBL1077343 | — | — | 1 | 6.65 |
| CHEMBL1077340 | — | — | 1 | 6.55 |
| CHEMBL401930 | — | — | 1 | 6.47 |
| CHEMBL256072 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505919 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL401766 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1077343 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL1077340 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL401930 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL256072 | — | IC50 | = | 376.0 | nM | 6.42 |