Assay Detail
Binding
CHEMBL1102709
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Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.71 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076724 | — | — | 1 | 8.82 |
| CHEMBL571492 | — | — | 1 | 8.48 |
| CHEMBL1076725 | — | — | 1 | 8.11 |
| CHEMBL1076726 | — | — | 1 | 8.09 |
| CHEMBL1076736 | — | — | 1 | 7.99 |
| CHEMBL1076737 | — | — | 1 | 7.79 |
| CHEMBL1076738 | — | — | 1 | 6.86 |
| CHEMBL1076740 | — | — | 1 | 6.75 |
| CHEMBL1076739 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076724 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL571492 | — | Ki | = | 3.317 | nM | 8.48 |
| CHEMBL1076725 | — | Ki | = | 7.78 | nM | 8.11 |
| CHEMBL1076726 | — | Ki | = | 8.06 | nM | 8.09 |
| CHEMBL1076736 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL1076737 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL1076738 | — | Ki | = | 138.7 | nM | 6.86 |
| CHEMBL1076740 | — | Ki | = | 176.9 | nM | 6.75 |
| CHEMBL1076739 | — | Ki | = | 343.5 | nM | 6.46 |