Assay Detail
Functional
CHEMBL1102809
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Antiviral activity against HIV1 infected human C8166 cells assessed as inhibition of viral replication after 4 days by p24 antigen capture ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.34 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1735 | INDINAVIR SULFATE | 4.0 | 1 | 8.09 |
| CHEMBL1080258 | PESTALOFICIOL J | — | 1 | 5.10 |
| CHEMBL1081525 | PESTALOFICIOL K | — | 1 | 4.11 |
| CHEMBL1079364 | PESTALOFICIOL G/H | — | 1 | 4.05 |
| CHEMBL1078031 | PESTALOFICIOL F | — | 1 | - |
| CHEMBL1080257 | PESTALOFICIOL I | — | 1 | - |
| CHEMBL1078132 | PESTALOFICIOL L | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1735 | INDINAVIR SULFATE | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL1080258 | PESTALOFICIOL J | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1081525 | PESTALOFICIOL K | EC50 | = | 78200.0 | nM | 4.11 |
| CHEMBL1079364 | PESTALOFICIOL G/H | EC50 | = | 89200.0 | nM | 4.05 |
| CHEMBL1078031 | PESTALOFICIOL F | EC50 | > | 100000.0 | nM | - |
| CHEMBL1080257 | PESTALOFICIOL I | EC50 | > | 100000.0 | nM | - |
| CHEMBL1078132 | PESTALOFICIOL L | EC50 | > | 100000.0 | nM | - |