Assay Detail
Binding
CHEMBL1102909
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Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.76 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081032 | — | — | 1 | 8.74 |
| CHEMBL1081834 | — | — | 1 | 8.18 |
| CHEMBL75729 | — | — | 1 | 8.00 |
| CHEMBL1080546 | — | — | 1 | 7.85 |
| CHEMBL1081835 | — | — | 1 | 7.80 |
| CHEMBL1081031 | — | — | 1 | 7.66 |
| CHEMBL1080753 | — | — | 1 | 7.10 |
| CHEMBL1081456 | — | — | 1 | 7.08 |
| CHEMBL1081969 | — | — | 1 | 7.01 |
| CHEMBL1081970 | — | — | 1 | 7.00 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.55 |
| CHEMBL1080547 | — | — | 1 | 6.47 |
| CHEMBL1079797 | — | — | 1 | 6.43 |
| CHEMBL1080387 | — | — | 1 | 6.37 |
| CHEMBL1080386 | PHENETHYLCYMSERINE | — | 1 | 6.27 |
| CHEMBL1081455 | — | — | 1 | 6.24 |
| CHEMBL1081085 | — | — | 1 | 6.01 |
| CHEMBL1081433 | — | — | 1 | 5.96 |
| CHEMBL1081457 | — | — | 1 | 5.85 |
| CHEMBL1081968 | — | — | 1 | 5.70 |
| CHEMBL1081652 | — | — | 1 | 5.23 |
| CHEMBL1081653 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081032 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1081834 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL75729 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1080546 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1081835 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1081031 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1080753 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1081456 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1081969 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1081970 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1080547 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1079797 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1080387 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1080386 | PHENETHYLCYMSERINE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1081455 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1081085 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1081433 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1081457 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1081968 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1081652 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1081653 | — | IC50 | = | 6700.0 | nM | 5.17 |