Compound Detail
CHEMBL1081653
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CN1c2ccc(OC(=O)Nc3ccc([N+](=O)[O-])cc3)cc2[C@]2(C)CCN(CCc3ccccc3)[C@H]12
Basic Information
| ChEMBL ID | CHEMBL1081653 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VOSDFYYUBRRDPZ-BDYUSTAISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
472.6
MW (Da)
5.19
ALogP
6
HBA
1
HBD
88.0
PSA (Ų)
0.39
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholinesterase CHEMBL2528 | IC50 | 5.17 | 5.17 | 6700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cholinesterase | IC50 | = | 6700.0 | nM | 5.17 | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric meth... | 20137941 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20137941 | 10.1016/j.bmcl.2010.01.035 | Acetylcholinesterase | 1 |
| 20137941 | 10.1016/j.bmcl.2010.01.035 | Cholinesterase | 1 |
| 20137941 | 10.1016/j.bmcl.2010.01.035 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine