Assay Detail
Binding
CHEMBL1102984
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Inhibition of PKCalpha
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and bioavailable GSK-3beta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.89 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26501 | RO-320432 | — | 1 | 7.66 |
| CHEMBL1082153 | — | — | 1 | 6.58 |
| CHEMBL1087243 | — | — | 1 | 6.42 |
| CHEMBL1082152 | — | — | 1 | 6.40 |
| CHEMBL1082151 | — | — | 1 | 6.13 |
| CHEMBL431933 | — | — | 1 | 6.12 |
| CHEMBL1081294 | — | — | 1 | 6.00 |
| CHEMBL1088724 | — | — | 1 | 5.98 |
| CHEMBL1081617 | — | — | 1 | 5.85 |
| CHEMBL1081972 | — | — | 1 | 5.85 |
| CHEMBL54547 | — | — | 1 | 5.72 |
| CHEMBL1081973 | — | — | 1 | 5.66 |
| CHEMBL1081128 | — | — | 1 | 5.54 |
| CHEMBL1081616 | — | — | 1 | 5.38 |
| CHEMBL1088149 | — | — | 1 | 5.26 |
| CHEMBL293542 | — | — | 1 | 5.22 |
| CHEMBL1087242 | — | — | 1 | 5.18 |
| CHEMBL53745 | — | — | 1 | 5.05 |
| CHEMBL1080933 | — | — | 1 | - |
| CHEMBL1086732 | — | — | 1 | - |
| CHEMBL1087380 | — | — | 1 | - |
| CHEMBL1081293 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26501 | RO-320432 | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1082153 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1087243 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1082152 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1082151 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL431933 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1081294 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1088724 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1081617 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1081972 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL54547 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1081973 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1081128 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1081616 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1088149 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL293542 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1087242 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL53745 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1080933 | — | IC50 | - | — | - | |
| CHEMBL1086732 | — | IC50 | - | — | - | |
| CHEMBL1087380 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1081293 | — | IC50 | - | — | - |