Assay Detail
Binding
CHEMBL1103280
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Inhibition of human recombinant CDK2/cyclin A expressed in baculovirus-infected insect Sf21 cells after 10 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.16 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077085 | — | — | 1 | 6.52 |
| CHEMBL1077107 | — | — | 1 | 6.40 |
| CHEMBL1087791 | RESCOVITINE | — | 1 | 6.30 |
| CHEMBL1083509 | — | — | 1 | 6.05 |
| CHEMBL1077070 | — | — | 1 | 6.05 |
| CHEMBL1087566 | — | — | 1 | 5.51 |
| CHEMBL1083817 | — | — | 1 | 5.42 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.16 |
| CHEMBL1086151 | — | — | 1 | 5.09 |
| CHEMBL1087440 | — | — | 1 | 4.99 |
| CHEMBL1077069 | — | — | 1 | 4.94 |
| CHEMBL1082230 | — | — | 1 | 4.64 |
| CHEMBL1087055 | — | — | 1 | 4.61 |
| CHEMBL1087054 | — | — | 1 | 4.59 |
| CHEMBL1077086 | — | — | 1 | 4.55 |
| CHEMBL1084117 | — | — | 1 | 4.35 |
| CHEMBL1084118 | — | — | 1 | 4.33 |
| CHEMBL1086152 | — | — | 1 | 4.32 |
| CHEMBL1077068 | — | — | 1 | 4.24 |
| CHEMBL1077095 | — | — | 1 | - |
| CHEMBL1088348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077085 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1077107 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1087791 | RESCOVITINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1083509 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1077070 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1087566 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1083817 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1086151 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1087440 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1077069 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1082230 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL1087055 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL1087054 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL1077086 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL1084117 | — | IC50 | = | 44900.0 | nM | 4.35 |
| CHEMBL1084118 | — | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL1086152 | — | IC50 | = | 48300.0 | nM | 4.32 |
| CHEMBL1077068 | — | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL1077095 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1088348 | — | IC50 | > | 100000.0 | nM | - |