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Assay Detail

CHEMBL1103345

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiinflammatory activity against mouse RAW264.7 cells assessed as Inhibition of LPS-induced nitric oxide production after 24 hrs by ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum.
Kuo YJ, Yang YC, Zhang LJ, Wu MD, Kuo LM, Kuo YC, Hwang SY, Chou CJ, Lee KH, Ho HO, Kuo YH.
J Nat Prod (2010) 73 : 109 -114
PubMed 20121165 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.57 4.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1077014 VISARTISIDE C 1 4.83
CHEMBL1077012 VISARTISIDE A 1 4.81
CHEMBL1083808 1 4.72
CHEMBL1086150 1 4.63
CHEMBL1077013 VISARTISIDE B 1 4.60
CHEMBL1077015 VISARTISIDE F 1 4.56
CHEMBL1094045 1 4.52
CHEMBL1090413 VISARTISIDE D 1 4.49
CHEMBL50 QUERCETIN 3.0 1 4.49
CHEMBL1082561 VISARTISIDE E 1 4.40
CHEMBL509624 1 4.38
CHEMBL469654 PRUNIN 1 4.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1077014 VISARTISIDE C IC50 = 14900.0 nM 4.83
CHEMBL1077012 VISARTISIDE A IC50 = 15600.0 nM 4.81
CHEMBL1083808 IC50 = 19200.0 nM 4.72
CHEMBL1086150 IC50 = 23400.0 nM 4.63
CHEMBL1077013 VISARTISIDE B IC50 = 25100.0 nM 4.60
CHEMBL1077015 VISARTISIDE F IC50 = 27800.0 nM 4.56
CHEMBL1094045 IC50 = 30200.0 nM 4.52
CHEMBL1090413 VISARTISIDE D IC50 = 32300.0 nM 4.49
CHEMBL50 QUERCETIN IC50 = 32100.0 nM 4.49
CHEMBL1082561 VISARTISIDE E IC50 = 39600.0 nM 4.40
CHEMBL509624 IC50 = 41200.0 nM 4.38
CHEMBL469654 PRUNIN IC50 = 42600.0 nM 4.37