Assay Detail
Binding
CHEMBL1103425
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Inhibition of MMP9 by fluorometric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.40 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092104 | — | — | 1 | 8.96 |
| CHEMBL1089843 | — | — | 1 | 8.46 |
| CHEMBL311932 | — | — | 1 | 8.32 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.32 |
| CHEMBL1090284 | — | — | 1 | 8.14 |
| CHEMBL1090647 | — | — | 1 | 8.07 |
| CHEMBL1088878 | — | — | 1 | 7.89 |
| CHEMBL561625 | — | — | 1 | 7.47 |
| CHEMBL550148 | — | — | 1 | 7.47 |
| CHEMBL1089842 | — | — | 1 | 7.34 |
| CHEMBL83508 | — | — | 1 | 6.89 |
| CHEMBL1090035 | — | — | 1 | 6.77 |
| CHEMBL1093690 | — | — | 1 | 6.72 |
| CHEMBL181244 | — | — | 1 | 6.70 |
| CHEMBL1090283 | — | — | 1 | 6.54 |
| CHEMBL1093689 | — | — | 1 | 6.37 |
| CHEMBL226439 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092104 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1089843 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL311932 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1090284 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1090647 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL1088878 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL561625 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL550148 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1089842 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL83508 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1090035 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1093690 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL181244 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1090283 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1093689 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL226439 | — | IC50 | = | 4100.0 | nM | 5.39 |