Assay Detail
Functional
CHEMBL1103518
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Antiviral activity against Influenza A virus Vietnam/1203/ 2004H/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.73 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089302 | — | — | 2 | 6.10 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.08 |
| CHEMBL1089502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089302 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1089302 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1089502 | — | EC50 | > | 41000.0 | nM | - |