Assay Detail
Binding
CHEMBL1103668
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Binding affinity to p38alpha by scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 9.79 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088796 | — | — | 1 | 10.30 |
| CHEMBL1092013 | — | — | 1 | 9.74 |
| CHEMBL1089865 | — | — | 1 | 9.60 |
| CHEMBL1091199 | — | — | 1 | 9.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088796 | — | Kd | = | 0.05 | nM | 10.30 |
| CHEMBL1092013 | — | Kd | = | 0.18 | nM | 9.74 |
| CHEMBL1089865 | — | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL1091199 | — | Kd | = | 0.31 | nM | 9.51 |