Assay Detail
ADMET
CHEMBL1103701
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Cytotoxicity against human MCF10A cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity and DNA-binding of novel bisnaphthalimidopropyl derivatives in breast cancer MDA-MB-231 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.68 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.75 |
| CHEMBL1098887 | — | — | 1 | 6.08 |
| CHEMBL1098888 | — | — | 1 | 6.06 |
| CHEMBL1098891 | — | — | 1 | 5.64 |
| CHEMBL268909 | BNIPDADEC | — | 1 | 5.55 |
| CHEMBL1098885 | BISNAPHTHALIMIDOPROPYL SPERMIDINE TRIHYDROBROMIDE | — | 1 | 5.40 |
| CHEMBL1098886 | — | — | 1 | 5.25 |
| CHEMBL1098890 | — | — | 1 | 5.24 |
| CHEMBL1098889 | — | — | 1 | 5.17 |
| CHEMBL1098892 | BISPHTHALIMIDOPROPYLDIAMINODECANE DIHYROBROMIDE | — | 1 | - |
| CHEMBL1095300 | NAPHTHALIMIDOPROPYLAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1098887 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1098888 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1098891 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL268909 | BNIPDADEC | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL1098885 | BISNAPHTHALIMIDOPROPYL SPERMIDINE TRIHYDROBROMIDE | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL1098886 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL1098890 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL1098889 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL1098892 | BISPHTHALIMIDOPROPYLDIAMINODECANE DIHYROBROMIDE | IC50 | > | 40000.0 | nM | - |
| CHEMBL1095300 | NAPHTHALIMIDOPROPYLAMINE | IC50 | > | 40000.0 | nM | - |