Assay Detail
Functional
CHEMBL1103713
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Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.39 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096567 | — | — | 1 | 8.06 |
| CHEMBL1096568 | — | — | 1 | 7.92 |
| CHEMBL1096880 | — | — | 1 | 7.75 |
| CHEMBL1096876 | — | — | 1 | 7.62 |
| CHEMBL1096881 | — | — | 1 | 7.50 |
| CHEMBL1096878 | — | — | 1 | 7.44 |
| CHEMBL1096877 | — | — | 1 | 7.07 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 6.96 |
| CHEMBL1096879 | — | — | 1 | 6.85 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096567 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1096568 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1096880 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1096876 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1096881 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1096878 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1096877 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1096879 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 180.0 | nM | 6.75 |