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Assay Detail

CHEMBL1103775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitumor activity against human ACHN cells after 48 hrs by MTT assay
21
Total Activities
19
Compounds Tested
4
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ACHN
Confidence 1 — Organism
Curated By Autocuration

Target

ACHN (CHEMBL614519)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents.
Chou LC, Huang LJ, Hsu MH, Fang MC, Yang JS, Zhuang SH, Lin HY, Lee FY, Teng CM, Kuo SC.
Eur J Med Chem (2010) 45 : 1395 -1402
PubMed 20097456 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.10 6.52
LC50 1 - -
TGI 1 - -
GI50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL333985 1 6.52
CHEMBL388917 1 6.40
CHEMBL1098956 1 6.22
CHEMBL1096929 1 6.05
CHEMBL1096928 1 5.72
CHEMBL1098935 1 5.66
CHEMBL1098941 1 -
CHEMBL1098566 1 -
CHEMBL1096288 1 -
CHEMBL1096632 1 -
CHEMBL1098612 1 -
CHEMBL1098613 1 -
CHEMBL1098937 1 -
CHEMBL1098936 3 -
CHEMBL1096930 1 -
CHEMBL1096931 1 -
CHEMBL1094294 1 -
CHEMBL1094295 1 -
CHEMBL1095939 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL333985 IC50 = 300.0 nM 6.52
CHEMBL388917 IC50 = 400.0 nM 6.40
CHEMBL1098956 IC50 = 600.0 nM 6.22
CHEMBL1096929 IC50 = 900.0 nM 6.05
CHEMBL1096928 IC50 = 1900.0 nM 5.72
CHEMBL1098935 IC50 = 2200.0 nM 5.66
CHEMBL1098936 TGI = 323.59 nM -
CHEMBL1098936 GI50 = 162.18 nM -
CHEMBL1098941 IC50 > 50000.0 nM -
CHEMBL1098566 IC50 > 100000.0 nM -
CHEMBL1096288 IC50 > 100000.0 nM -
CHEMBL1096632 IC50 > 100000.0 nM -
CHEMBL1098612 IC50 > 100000.0 nM -
CHEMBL1098613 IC50 > 100000.0 nM -
CHEMBL1098936 LC50 < 630.96 nM -
CHEMBL1095939 IC50 > 100000.0 nM -
CHEMBL1096930 IC50 > 100000.0 nM -
CHEMBL1096931 IC50 > 100000.0 nM -
CHEMBL1094294 IC50 > 100000.0 nM -
CHEMBL1094295 IC50 > 100000.0 nM -
CHEMBL1098937 IC50 > 100000.0 nM -