Assay Detail
Functional
CHEMBL1104085
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Cytotoxicity against human MDA-MB-231 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive scalaranes from the Thai sponge Hyrtios gumminae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.12 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.52 |
| CHEMBL1078661 | HYRTIOSAL | — | 1 | 5.27 |
| CHEMBL250263 | — | — | 1 | 5.23 |
| CHEMBL1078681 | SCALARAFURAN | — | 1 | 4.85 |
| CHEMBL1078884 | HYRTIOLIDE | — | 1 | 4.58 |
| CHEMBL1079330 | SIMILAN A | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1078661 | HYRTIOSAL | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL250263 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1078681 | SCALARAFURAN | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1078884 | HYRTIOLIDE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1079330 | SIMILAN A | IC50 | = | 58000.0 | nM | 4.24 |