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Compound Detail

CHEMBL1078681

SCALARAFURAN
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CC(=O)O[C@H]1C[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(C)[C@H]3C[C@@H](O)[C@]2(C)c2cocc21

Basic Information

ChEMBL ID CHEMBL1078681
Name SCALARAFURAN
Phase Preclinical
Structure Type MOL
InChI Key JRKYCNUZXAQLDW-PVRRMCBNSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

428.6
MW (Da)
6.17
ALogP
4
HBA
1
HBD
59.7
PSA (Ų)
0.54
QED
1
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C27H40O4
MW 428.61
Aromatic Rings 1
Heavy Atoms 31
NP-Likeness 2.96

Activity Summary

IC50 6 meas. best 4.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
MDA-MB-231
CHEMBL400
IC50 4.85 4.85 14000.0 1
T47D
CHEMBL614361
IC50 4.55 4.55 28000.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.31 4.31 49000.0 1
NCI-H69
CHEMBL614805
IC50 4.29 4.29 51000.0 1
KB
CHEMBL398
IC50 4.24 4.24 58000.0 1
HeLa
CHEMBL399
IC50 4.2 4.2 63000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19788270 10.1021/np900267v NON-PROTEIN TARGET 1
19788270 10.1021/np900267v KB 1
19788270 10.1021/np900267v HeLa 1
19788270 10.1021/np900267v MDA-MB-231 1
19788270 10.1021/np900267v T47D 1
19788270 10.1021/np900267v NCI-H69 1
19658408 10.1021/np900326a SK-OV-3 1
19658408 10.1021/np900326a SK-MEL 1
19658408 10.1021/np900326a BT-549 1
19658408 10.1021/np900326a Vero 1
19658408 10.1021/np900326a Staphylococcus aureus 1
19658408 10.1021/np900326a Mycobacterium intracellulare 1

Data from ChEMBL 36 via Core Engine