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Target Snapshot

CHEMBL614361 Target Snapshot

T47D · CELL-LINE · Homo sapiens

33,898Compounds
2,483Assays
66Approved Drugs
4,355.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats T47D as ChEMBL target CHEMBL614361. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
T47D
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614361
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether T47D still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelT47D
UniProt AccessionN/A

T47D

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as T47D.

Review nameT47D
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

66
Approved
30
Phase III
34
Phase II
12
Phase I
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC503,450.0
KI49.0
EC50856.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL373114 10.1 IC50 0.08 Preclinical
CHEMBL190015 10.0 EC50 0.1 Preclinical
CHEMBL191197 10.0 EC50 0.1 Preclinical
CHEMBL3218975 10.0 IC50 0.1 Preclinical
CHEMBL425005 9.82 EC50 0.15 Preclinical
CHEMBL539163 9.82 EC50 0.15 Clinical
CHEMBL107 9.55 IC50 0.28 Approved
CHEMBL4447340 9.54 IC50 0.29 Preclinical
CHEMBL193239 9.46 EC50 0.35 Preclinical
CHEMBL282650 9.4 EC50 0.4 Preclinical
Distribution

pChEMBL Value Distribution

666
5.0
641
5.5
430
6.0
247
6.5
207
7.0
165
7.5
109
8.0
45
8.5
20
9.0
4
9.5
pChEMBL
Approved Drugs

Approved Drugs

CAPIVASERTIB
CHEMBL2325741
Approved 2023
ALPELISIB
CHEMBL2396661
Approved 2019
ABEMACICLIB
CHEMBL3301610
Approved 2017
PALBOCICLIB
CHEMBL189963
Approved 2015
PANOBINOSTAT
CHEMBL483254
Approved 2015
IDELALISIB
CHEMBL2216870
Approved 2014
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
DASATINIB
CHEMBL5416410
Approved 2006
SORAFENIB
CHEMBL1336
Approved 2005
FULVESTRANT
CHEMBL1358
Approved 2002
NILUTAMIDE
CHEMBL1274
Approved 1996
TOPOTECAN
CHEMBL84
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
CLADRIBINE
CHEMBL1619
Approved 1993
PACLITAXEL
CHEMBL428647
Approved 1992
AMSACRINE
CHEMBL43
Approved 1987
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
CALCITRIOL
CHEMBL846
Approved 1978
TAMOXIFEN
CHEMBL83
Approved 1977
DIGOXIN
CHEMBL1751
Approved 1975
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
DOXORUBICIN
CHEMBL53463
Approved 1974
TRETINOIN
CHEMBL38
Approved 1971
VINBLASTINE
CHEMBL159
Approved 1965
VINCRISTINE
CHEMBL90555
Approved 1963
FLUOROURACIL
CHEMBL185
Approved 1962
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
DISULFIRAM
CHEMBL964
Approved 1951
Assay Landscape

Assay Landscape

2,483
Total Assays
2,904
Tested Compounds
4
Assay Types
Functional — 2,447 assays, 2,904 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2,438 2,904 5.8
organism-based format 9 0
ADME — 30 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 30 12 4.5
Unassigned — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 0
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine