Compound Detail
CHEMBL539163
TANAPROGET 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL539163 |
| Name | TANAPROGET |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | PYVFWTPEBMRKSR-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
11
Publications
2
Known Names
Molecular Properties
297.4
MW (Da)
3.53
ALogP
4
HBA
1
HBD
50.0
PSA (Ų)
0.82
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
EC50 2 meas. best 9.82
IC50 1 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | EC50 | 9.82 | 9.82 | 0.1 | 1 |
| T47D CHEMBL614361 | EC50 | 9.82 | 9.82 | 0.1 | 1 |
| Progesterone receptor CHEMBL208 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| T47D | EC50 | = | 0.15 | nM | 9.82 | Effective concentration against alkaline phosphatase activity in human T47D brea... | 16078826 |
| Progesterone receptor | EC50 | = | 0.15 | nM | 9.82 | Agonist activity at human PR expressed in human T47D cells assessed as stimulati... | 18318463 |
| Progesterone receptor | IC50 | = | 0.5 | nM | 9.3 | Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay | 18318463 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 18318463 | 10.1021/jm701080t | Progesterone receptor | 2 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 16078826 | 10.1021/jm050358b | T47D | 1 |
| 17681796 | 10.1016/j.bmc.2007.07.011 | Cynomolgus monkey | 1 |
| 20355713 | 10.1021/jm100052k | Progesterone receptor | 1 |
| - | 10.6019/CHEMBL3301361 | ADMET | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/EOS300108 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine