Assay Detail
Functional
CHEMBL834408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against alkaline phosphatase activity in human T47D breast carcinoma cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 9.18 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190015 | — | — | 1 | 10.00 |
| CHEMBL191197 | — | — | 1 | 10.00 |
| CHEMBL425005 | — | — | 1 | 9.82 |
| CHEMBL539163 | TANAPROGET | 2.0 | 1 | 9.82 |
| CHEMBL193239 | — | — | 1 | 9.46 |
| CHEMBL282650 | — | — | 1 | 9.40 |
| CHEMBL191589 | — | — | 1 | 9.30 |
| CHEMBL67860 | — | — | 1 | 8.96 |
| CHEMBL282649 | — | — | 1 | 8.92 |
| CHEMBL370949 | — | — | 1 | 7.68 |
| CHEMBL165612 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190015 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL191197 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL425005 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL539163 | TANAPROGET | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL193239 | — | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL282650 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL191589 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL67860 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL282649 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL370949 | — | EC50 | = | 21.1 | nM | 7.68 |
| CHEMBL165612 | — | EC50 | = | 23.0 | nM | 7.64 |