Evidence Snapshot

T47D

CHEMBL614361 CELL-LINE Homo sapiens

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T16:06:29Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 1:06 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL614361

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats T47D as ChEMBL target CHEMBL614361. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

T47D

CELL-LINE · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL614361

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why T47D matters

As of 2026-09-13

T47D is reviewed as T47D; the current evidence base includes 66 approved drugs, 33898 compounds, and 2483 assays, with lead potency reaching pChEMBL 10.1.

Protein context

T47D

Review this target as T47D.

Protein source · UniProt accession via ChEMBL component mapping

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 66 approved drugs, 33898 compounds, and 2483 assays for this target. The dominant activity type is IC50. CHEMBL373114 is the current potency anchor at pChEMBL 10.1.

Use CHEMBL373114 as the tractability anchor when discussing potency (pChEMBL 10.1).

Activity source · ChEMBL 36 via Core Engine

66 approved pChEMBL 10.1

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why T47D matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

33898

Total Compounds

2483

Total Assays

Approved Drugs

IC50: 3450.0, KI: 49.0, EC50: 856.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL373114	10.1	IC50	—
No preferred name CHEMBL190015	10.0	EC50	—
No preferred name CHEMBL191197	10.0	EC50	—
No preferred name CHEMBL3218975	10.0	IC50	—
No preferred name CHEMBL425005	9.8	EC50	—

Approved Drugs

Structure	Compound	First Approval
	CAPIVASERTIB CHEMBL2325741	2023
	ALPELISIB CHEMBL2396661	2019
	ABEMACICLIB CHEMBL3301610	2017
	PALBOCICLIB CHEMBL189963	2015
	PANOBINOSTAT CHEMBL483254	2015
	IDELALISIB CHEMBL2216870	2014
	TEMSIROLIMUS CHEMBL1201182	2007
	DASATINIB CHEMBL5416410	2006
	SORAFENIB CHEMBL1336	2005
	FULVESTRANT CHEMBL1358	2002
	NILUTAMIDE CHEMBL1274	1996
	TOPOTECAN CHEMBL84	1996
	DOCETAXEL CHEMBL3545252	1995
	VINORELBINE CHEMBL553025	1994
	CLADRIBINE CHEMBL1619	1993
	PACLITAXEL CHEMBL428647	1992
	AMSACRINE CHEMBL43	1987
	ETOPOSIDE CHEMBL44657	1983
	MITOMYCIN CHEMBL105	1981
	CALCITRIOL CHEMBL846	1978
	TAMOXIFEN CHEMBL83	1977
	DIGOXIN CHEMBL1751	1975
	DOXORUBICIN HYDROCHLORIDE CHEMBL359744	1974
	DOXORUBICIN CHEMBL53463	1974
	TRETINOIN CHEMBL38	1971
	VINBLASTINE CHEMBL159	1965
	VINCRISTINE CHEMBL90555	1963
	FLUOROURACIL CHEMBL185	1962
	COLCHICINE CHEMBL107	1961
	METHOTREXATE CHEMBL34259	1953
	DISULFIRAM CHEMBL964	1951

← Target Page

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T16:06:29Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 1:06 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL614361